Virological control by the CD4-binding site antibody N6 in simian-human immunodeficiency virus-infected rhesus monkeys

B Julg, A Pegu, P Abbink, J Liu, A Brinkman… - Journal of …, 2017 - Am Soc Microbiol
… of the human immunodeficiency virus type 1 (HIV-1) envelope … -specific CD8 + T-cell responses
following bnAb treatment. … as being characteristic of SF162 viruses that had undergone a …

The nef protein of the macrophage tropic HIV-1 strain AD8 counteracts human BST-2/Tetherin

S Giese, SP Lawrence, M Mazzon, BM Nijmeijer… - Viruses, 2020 - mdpi.com
… , HIV-2 does not express Vpu but has adapted its envelope (Env) … 2693BA and the HIV-2
strain 7312 showed smaller effects (… Human immunodeficiency virus type 1 (HIV-1) AD8-infected …

[HTML][HTML] Toward a macaque model of HIV-1 infection: Roadblocks, progress, and future strategies

R Thippeshappa, JT Kimata, D Kaushal - Frontiers in Microbiology, 2020 - frontiersin.org
line resulted in an in vitro adapted HIV-1 derivative (NL-DT5R), which replicated well in the
CM T-cell line (… region of simian immunodeficiency virus SIVgsn166 vpu. The resultant clone, …

[HTML][HTML] A single gp120 residue can affect HIV-1 tropism in macaques

GQ Del Prete, BF Keele, J Fode, K Thummar… - PLoS …, 2017 - journals.plos.org
T-cell line [29]. The parental SHIV 1054 replicated efficiently is 221 cells as did the majority of
SHIVs expressing adapted … Env and maintains macrophage tropism in pigtail macaques [23…

HIV-1 propagation is highly dependent on basal levels of the restriction factor BST2

B Olety, P Peters, Y Wu, Y Usami, H Göttlinger - Science Advances, 2021 - science.org
… In contrast to HIV-1, most simian immunodeficiency virusesVpu without altering the vpu
initiation codon did not affect Env … T cell line is exceptionally susceptible to infection with cell-free …

Characterization of HIV-2 Susceptibility to Protease and Entry Inhibitors and Identification of Envelope Determinants of Coreceptor Usage, Cell Tropism and Antibody …

AR Martins - 2018 - search.proquest.com
… activity against human immunodeficiency virus type 1 (HIV-1)… of co-receptor use, macrophage
tropism and susceptibility to … + T cell counts and lower or undetectable plasma viral loads, …

TRANSGENE IL-21-ENGINEERED ANTIGEN-SPECIFIC EXOSOME TARGETED T CELL-BASED VACCINE POTENTLY CONVERTS CTL EXHAUSTION IN CHRONIC …

X Zhang - 2018 - harvest.usask.ca
… such as human immunodeficiency virus (HIV)-1. We … a lipid envelope, which contains viral
envelope glycoproteins … initial HIV-1 strain, is that the outnumbered CD4+ T cell that prevents …

[HTML][HTML] Selective use of primate CD4 receptors by HIV-1

CJ Warren, NR Meyerson, O Dirasantha… - PLoS …, 2019 - journals.plos.org
… (Env) protein of these virions interacts with the T-cell receptor … Envs (BaL or SF162) was
neutralized by human sCD4 to an … engineered or adapted to bind CD4 more tightly. The fact …

[HTML][HTML] Sensitivity to monoclonal antibody 447-52D and an open env trimer conformation correlate poorly with inhibition of HIV-1 infectivity by SERINC5

AO Angerstein, CA Stoneham, PW Ramirez… - Virology, 2020 - Elsevier
… usually found in laboratory-adapted strains that are easily … sensitive to SERINC5 (LAI and
SF162) and three of which we … Human immunodeficiency virus type 1 env clones from acute …

[HTML][HTML] Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analyses

SBH Gumbs, R Kübler, L Gharu, PJ Schipper… - Journal of …, 2022 - Springer
… , the main viral CNS reservoir, is imperative. Here, we provide a comprehensive comparison
of human microglial culture models: cultured primary microglia (pMG), microglial cell lines, …